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Vesicular stomatitis virus Pseudotyped with SARS-CoV-2 Spike Glycoprotein, United Kingdom Variant
Catalog #:
EG-352
Please Choose:
Size
100 µl ( $980.00 )
1 ml ( $8,000.00 )
Qty:
Product Name
Vesicular Stomatitis Virus (VSV) Pseudotyped with SARS-CoV-2 Spike Glycoprotein, HexaPro Stabilized Trimer, United Kingdom Variant
Description
Vesicular stomatitis virus particles pseudotyped with SARS‑CoV‑2 spike glycoprotein, with hexaPro mutations so the surface protein antigenically optimal pre-fusion conformation, produced and purified from HEK 293 cells. This pseudovirus has N501Y mutation.
Mutations
Furin site RRAR mutated to GSAS; HexaPro mutations (K986P, V987P, F817P, A892P, A899P and A942P) to ensure the S glycoprotein remains in an antigenically optimal pre-fusion conformation.
United Kingdom mutations: N501Y
Source
HEK293T cells
Reporter
EGFP
Application
Screening of SARS‑CoV‑2 neutralizing antibodies
Assessment of vaccine efficacy
Titer
> 1 X 10
7
RFU/ml or > 1 X 10
5
TU/ml
Shipping
Dry ice
Storage
-80 oC
References
Generation of VSV Pseudotypes Using Recombinant ΔG-VSV for Studies on Virus Entry, Identification of Entry Inhibitors, and Immune Responses to Vaccines Sci Rep 10, 19076 (2020).
doi:10.1016%2Fj.jviromet.2010.08.006
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